Real-time tumor tracking during treatment delivery gives us the confidence that we target mobile liver tumors accurately and minimize geographical miss.
MR-Guided radiation therapy for liver cancer
Deliver SBRT with certainty
Deliver ablative doses
Reduce margins
Offer fiducial-free treatment
Liver tumors pose unique challenges in radiation therapy due to their difficult visualization on CT scans without contrast. Additionally, inter- and intrafraction target motion often requires large margin extensions, complicating the delivery of ablative doses (≥75Gy BED10) needed for successful treatment.
High-field MR-guided radiation therapy (MRgRT) allows superb visualization of the tumor and OARs, without the need for implanted markers or contrast. The ability to adapt to small changes in patient anatomy enables clinicians to optimize and escalate dose. Together with real-time tumor tracking and automatic gating this enables the use of small margins - even for mobile targets - and sparing of healthy tissue, such as liver parenchyma. As a result, MRgRT potentially reduces toxicity compared to traditional CBCT approaches and opens avenues for curative-intent radiotherapy in patients with difficult-to-treat liver tumors.
Safely deliver ablative doses. Reduce margins with certainty. Offer a non-invasive alternative to surgery with fiducial-free treatment.
Clinical benefits
Elekta Unity MR-guided radiation therapy for liver cancer
With superior soft-tissue contrast, precise target identification and online adaptive treatment, Elekta Unity allows you to deliver SBRT with certainty and enhance outcomes for liver cancer patients.
- Safely deliver ablative doses with curative intent
- Accurately target mobile tumors with inter- and intrafraction motion management
- Spare sensitive structures, such as liver parenchyma, and reduce side effects
- Offer non-invasive treatment and increase patient eligibility
See the difference for liver cancer treatments
Superior visualization of target and OARs
MRI provides superior soft-tissue contrast visualizing the target and surrounding sensitive structures with great detail and resolution and without the need for contrast.
Images courtesy of Genesis Care St Vincent’s Clinic, Sydney, Australia
Deliver SBRT with certainty
Superior visualization of the liver target and online plan adaption enable delivery of ablative doses for improved local control without increasing toxicity.
Video courtesy of Genesis Care St Vincent’s Clinic, Sydney, Australia
See more clearly
Advanced MR imaging sequences, such as 3D Vane XD, reveal the anatomical relationship between the target and surrounding healthy organs at each fraction. With more accurate target definition and smaller margins, SBRT can be delivered with certainty.
Images courtesy of IRCCS Ospedale Sacro Cuore don Calabria, Italy
Adjust the treatment plan based on target response
Daily MR imaging can reveal changes in tumor size and allow daily plan adaptation to acount for target response and reduce radiation to healthy tissue.
Images courtesy of Tübingen University Hospital, Germany
Account for intrafraction motion
Liver tumors can be highly mobile. With True tracking and automatic gating intrafraction motion is monitored and accounted for, ensuring treatment is always focused on the target. This offers the potential to further reduce margins, stimulate further hypofractionation, escalate dose and ultimately reduce side effects and drive outcomes.
Video courtesy of Negrar
Clinical evidence
Learn more about how MR-guided radiation therapy is benefiting liver cancer patients
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Indications
Explore the benefits of Elekta Unity for highlighted indications
References
1. https://seer.cancer.gov/statfacts/html/common.html
2. Adapted from Tringale et al. Stereotactic ablative radiation for pancreatic cancer on a 1.5 Telsa magnetic resonance-linac system. doi: 10.1016/j.phro.2022.10.003. Licenced by CC B